1160271-30-6
1160271-30-6 structure
- Name: PPTN
- Chemical Name: PPTN trifluoroacetate salt
- CAS Number: 1160271-30-6
- Molecular Formula: C29H24F3NO2
- Molecular Weight: 589.525
- Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
- Create Date: 2020-01-11 16:12:00
- Modify Date: 2024-01-11 10:38:39
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PPTN is a potent, highly specific amtagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays; exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM; inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.
| Name | PPTN trifluoroacetate salt |
|---|---|
| Synonyms |
4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthoic acid trifluoroacetate (1:1)
4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid trifluoroacetate salt 2-Naphthalenecarboxylic acid, 4-[4-(4-piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-, compd. with 2,2,2-trifluoroacetic acid (1:1) PPTN trifluoroacetate salt |
| Description | PPTN is a potent, highly specific amtagonist of P2Y14 receptor with Ki of 0.4 nM in functional assays; exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors at 1 uM; inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. |
|---|---|
| References | References 1. Yu J, et al. J Med Chem. 2018 May 16. doi: 10.1021/acs.jmedchem.8b00168. 2. Junker A, et al. J Med Chem. 2016 Jul 14;59(13):6149-68. 3. Kiselev E, et al. ACS Chem Biol. 2014 Dec 19;9(12):2833-42. 4. Barrett MO, et al. Mol Pharmacol. 2013 Jul;84(1):41-9. View Related Products by Target P2Y Receptor |
| Molecular Formula | C29H24F3NO2 |
|---|---|
| Molecular Weight | 589.525 |
| Exact Mass | 589.168762 |