1162656-24-7
1162656-24-7 structure
- Name: Nexinhib 20
- Chemical Name: 4,4-Dimethyl-1-(3-nitro-phenyl)-2-[1,2,4]triazol-1-yl-pent-1-en-3-one
- CAS Number: 1162656-24-7
- Molecular Formula: C15H16N4O3
- Molecular Weight: 300.313
- Create Date: 2020-01-13 17:24:50
- Modify Date: 2024-01-14 14:06:57
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Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors; does not induce apoptosis or cell death, regulates exocytosis-dependent neutrophil functions and inhibits MPO secretion from human neutrophils; also reversiblely and potently inhibits extracellular production of superoxide anion and the up-regulation of activation signature molecules, including CD11b and CD66b; significantly decreased tissue infiltration by inflammatory neutrophils in vivo.
| Name | 4,4-Dimethyl-1-(3-nitro-phenyl)-2-[1,2,4]triazol-1-yl-pent-1-en-3-one |
|---|---|
| Synonyms |
(1Z)-4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-one
4,4-Dimethyl-1-(3-nitro-phenyl)-2-[1,2,4]triazol-1-yl-pent-1-en-3-one (1Z)-4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one MFCD00219515 1-Penten-3-one, 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-, (1Z)- 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-one (Z)-4,4-Dimethyl-1-(3-nitro-phenyl)-2-[1,2,4]triazol-1-yl-pent-1-en-3-one |
| Description | Nexinhib 20 is a novel small molecule neutrophil exocytosis inhibitor (IC50=0.33 uM) that specifically inhibits Rab27a-JFC1 binding (IC50=2.6 uM) but does not interfere with the interaction of other Rab GTPases and effectors; does not induce apoptosis or cell death, regulates exocytosis-dependent neutrophil functions and inhibits MPO secretion from human neutrophils; also reversiblely and potently inhibits extracellular production of superoxide anion and the up-regulation of activation signature molecules, including CD11b and CD66b; significantly decreased tissue infiltration by inflammatory neutrophils in vivo. |
|---|---|
| References | References 1. Johnson JL, et al. J Biol Chem. 2016 Dec 9;291(50):25965-25982. View Related Products by Target Small GTPase |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 508.2±60.0 °C at 760 mmHg |
| Molecular Formula | C15H16N4O3 |
| Molecular Weight | 300.313 |
| Flash Point | 261.2±32.9 °C |
| Exact Mass | 300.122253 |
| LogP | 2.50 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.601 |