1204480-26-1
1204480-26-1 structure
- Name: ER 27319 maleate
- Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone (2Z)-2-butenedioate (1:1)
- CAS Number: 1204480-26-1
- Molecular Formula: C18H20N2O.C4H4O4
- Molecular Weight: 396.436
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Syk
- Create Date: 2020-01-12 01:36:50
- Modify Date: 2023-01-14 21:25:43
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ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk; does not inhibits the anti-CD3-induced tyrosine phosphorylation of phospholipase C-gamma1 in Jurkat T cells.
| Name | 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone (2Z)-2-butenedioate (1:1) |
|---|---|
| Synonyms |
10-(3-Aminopropyl)-3,4-dimethylacridin-9(10H)-one (2Z)-but-2-enedioate (1:1)
9(10H)-Acridinone, 10-(3-aminopropyl)-3,4-dimethyl-, (2Z)-2-butenedioate (1:1) 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone (2Z)-2-butenedioate (1:1) |
| Description | ER-27319 maleate is a potent, selective inhibitor of antigen or anti-IgE-mediated degranulation of rodent and human mast cells by selective inhibition of FcɛRI-mediated activation of Syk; does not inhibits the anti-CD3-induced tyrosine phosphorylation of phospholipase C-gamma1 in Jurkat T cells. |
|---|---|
| References | References 1. Moriya K, et al. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12539-44. 2. Andrews RP, et al. J Leukoc Biol. 2001 Nov;70(5):776-82. View Related Products by Target Syk |
| Molecular Formula | C18H20N2O.C4H4O4 |
|---|---|
| Molecular Weight | 396.436 |
| Exact Mass | 396.168518 |