1219728-20-7

1219728-20-7 structure

Name: SR 7826
Chemical Name: 1-(2-Hydroxyethyl)-3-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-phenylurea
CAS Number: 1219728-20-7
Molecular Formula: C₂₂H₂₁N₅O₂
Molecular Weight: 387.434
Catalog: Signaling Pathways Cell Cycle/DNA Damage LIM Kinase (LIMK)
Create Date: 2020-01-12 14:45:20
Modify Date: 2024-04-03 17:21:57
SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM, displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold); inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases; potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 <1 uM), suppresses migration and invasion of PC-3 cells in vitro.

Name	1-(2-Hydroxyethyl)-3-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-phenylurea
Synonyms	MFCD29081182 1-(2-Hydroxyethyl)-3-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-1-phenylurea Urea, N-(2-hydroxyethyl)-N'-[4-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]-N-phenyl-

Description	SR7826 is a potent and selective LIM kinase (LIMK) inhibitor with IC50 of 43 nM, displays >100-fold selectivity over ROCK1 and ROCK2, as well as JNK kinases (>400-fold); inhibits only Limk1 and STK16 with >80% inhibition at 1 uM in a panel of 61 kinases; potently inhibits cofilin phosphorylation in A7r5, PC-3, and CEM-SS T cells (IC50 <1 uM), suppresses migration and invasion of PC-3 cells in vitro.
References	References 1. Yu Q, et al. Br J Pharmacol. 2018 Jun;175(11):2077-2096. 2. Yin Y, et al. J Med Chem. 2015 Feb 26;58(4):1846-61. View Related Products by Target LIM Kinase (LIMK)