1346526-26-8

1346526-26-8 structure

Name: Sibiriline
Chemical Name: 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
CAS Number: 1346526-26-8
Molecular Formula: C₁₃H₁₀N₂O
Molecular Weight: 210.231
Create Date: 2020-01-11 22:30:36
Modify Date: 2024-01-09 12:44:24
A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.

Name	4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
Synonyms	Phenol, 4-(1H-pyrrolo[2,3-b]pyridin-2-yl)- 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol

Description	A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.
References	References 1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176. View Related Products by Target RIP kinase