1346526-26-8
1346526-26-8 structure
- Name: Sibiriline
- Chemical Name: 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
- CAS Number: 1346526-26-8
- Molecular Formula: C13H10N2O
- Molecular Weight: 210.231
- Create Date: 2020-01-11 22:30:36
- Modify Date: 2025-08-25 14:41:04
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A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis.
| Name | 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol |
|---|---|
| Synonyms |
Phenol, 4-(1H-pyrrolo[2,3-b]pyridin-2-yl)-
4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol |
| Description | A specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3; inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM); selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis; protects mice from concanavalin A-induced hepatitis. |
|---|---|
| References | References 1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176. View Related Products by Target RIP kinase |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 457.4±30.0 °C at 760 mmHg |
| Molecular Formula | C13H10N2O |
| Molecular Weight | 210.231 |
| Flash Point | 230.4±24.6 °C |
| Exact Mass | 210.079315 |
| LogP | 3.59 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.726 |