1400902-13-7

1400902-13-7 structure

Name: CORT 118335
Chemical Name: 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
CAS Number: 1400902-13-7
Molecular Formula: C₂₄H₂₃F₃N₂O₂
Molecular Weight: 428.447
Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
Create Date: 2020-01-11 15:58:49
Modify Date: 2024-02-24 09:54:04
CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.

Name	6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
Synonyms	6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione 2,4(1H,3H)-Pyrimidinedione, 6-(4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]-

Description	CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.
In Vitro	CORT 118335 (Miricorilant, C118335)?is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo.