1400902-13-7
1400902-13-7 structure
- Name: CORT 118335
- Chemical Name: 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
- CAS Number: 1400902-13-7
- Molecular Formula: C24H23F3N2O2
- Molecular Weight: 428.447
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2020-01-11 15:58:49
- Modify Date: 2024-02-24 09:54:04
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CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.
| Name | 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione |
|---|---|
| Synonyms |
6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-(4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]- |
| Description | CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR. |
|---|---|
| In Vitro | CORT 118335 (Miricorilant, C118335)?is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H23F3N2O2 |
| Molecular Weight | 428.447 |
| Exact Mass | 428.171173 |
| LogP | 6.21 |
| Index of Refraction | 1.562 |