1431980-60-7

1431980-60-7 structure

Name: TASP 0433864
Chemical Name: (2S)-5-Methyl-2-{[4-(2-methyl-2-propanyl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide
CAS Number: 1431980-60-7
Molecular Formula: C₁₈H₂₃N₃O₃
Molecular Weight: 329.393
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2020-01-19 23:30:56
Modify Date: 2024-01-02 15:44:11
A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity; has negligible activities for other mGlu receptors, including mGlu3 receptor; potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram; significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice.

Name	(2S)-5-Methyl-2-{[4-(2-methyl-2-propanyl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide
Synonyms	MFCD30720884 (2S)-5-Methyl-2-{[4-(2-methyl-2-propanyl)phenoxy]methyl}-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide Imidazo[2,1-b]oxazole-6-carboxamide, 2-[[4-(1,1-dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methyl-, (2S)-

Description	A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity; has negligible activities for other mGlu receptors, including mGlu3 receptor; potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram; significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice.
References	References 1. Hiyoshi T, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):642-53. View Related Products by Target mGluR