1443321-11-6
1443321-11-6 structure
- Name: Divin
- Chemical Name: N'-[(E)-(2-Hydroxy-1-naphthyl)methylene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide
- CAS Number: 1443321-11-6
- Molecular Formula: C22H20N4O2
- Molecular Weight: 372.420
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-01-11 11:20:56
- Modify Date: 2024-01-15 05:41:05
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A potent chelator of iron that arrests late stages of cytokinesis by blocking the physical process of constriction in dividing cells; also is a small molecule inhibitor of bacterial divisome assembly; downregulates the transcription of genes encoding proteins involved in cell division, reduce protein biosynthesis, and affects the spatiotemporal localization of the division machinery.
| Name | N'-[(E)-(2-Hydroxy-1-naphthyl)methylene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide |
|---|---|
| Synonyms |
N'-[(E)-(2-Hydroxy-1-naphthyl)methylene]-3-(2-methyl-1H-benzimidazol-1-yl)propanehydrazide
MFCD03664181 1H-Benzimidazole-1-propanoic acid, 2-methyl-, 2-[(1E)-(2-hydroxy-1-naphthalenyl)methylene]hydrazide |
| Description | A potent chelator of iron that arrests late stages of cytokinesis by blocking the physical process of constriction in dividing cells; also is a small molecule inhibitor of bacterial divisome assembly; downregulates the transcription of genes encoding proteins involved in cell division, reduce protein biosynthesis, and affects the spatiotemporal localization of the division machinery. |
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| References | References 1. Santos TMA, et al. ACS Chem Biol. 2017 Dec 11. doi: 10.1021/acschembio.7b00560. 2. Eun YJ, et al. J Am Chem Soc. 2013 Jul 3;135(26):9768-76. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C22H20N4O2 |
| Molecular Weight | 372.420 |
| Exact Mass | 372.158630 |
| LogP | 5.37 |
| Index of Refraction | 1.667 |
| RIDADR | NONH for all modes of transport |
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