1803003-68-0
1803003-68-0 structure
- Name: RN-9893
- Chemical Name: RN-9893
- CAS Number: 1803003-68-0
- Molecular Formula: C21H23F3N4O5S
- Molecular Weight: 500.491
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2020-01-20 10:20:55
- Modify Date: 2024-04-11 21:33:27
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A potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively; >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets.
| Name | RN-9893 |
|---|---|
| Synonyms |
N-{4-[(4-Isopropyl-1-piperazinyl)sulfonyl]phenyl}-2-nitro-4-(trifluoromethyl)benzamide
Benzamide, N-[4-[[4-(1-methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)- MFCD29917838 RN-9893 N-(4-(4-Isopropylpiperazin-1-ylsulfonyl)phenyl)-2-nitro-4-(trifluoromethyl)benzamide |
| Description | A potent, selective orally-bioavailable TRPV4 antagonist with IC50 of 320, 420 and 660 nM for mouse, human and rat TRPV4 channels, respectively; >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. |
|---|---|
| References | References 1. Wei ZL, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4011-5. View Related Products by Target TRP Channel |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H23F3N4O5S |
| Molecular Weight | 500.491 |
| Exact Mass | 500.134125 |
| LogP | 4.26 |
| Index of Refraction | 1.584 |
| RIDADR | NONH for all modes of transport |
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