2109805-96-9

2109805-96-9 structure

Name: BAY 707
Chemical Name: N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
CAS Number: 2109805-96-9
Molecular Formula: C₁₅H₂₀N₄O₂
Molecular Weight: 288.345
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2020-01-12 11:19:33
Modify Date: 2024-01-03 19:20:26
BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM; demonstrates high selectivity in an in-house kinase panel, and shows an overall favorable physicochemical profile and in vitro pharmacokinetic properties with high metabolic stability; demonstrates a superior cellular target engagement with an EC50 of 7.6 nM compared with TH588, increases the cellular thermal stabilization of MTH1 with no effect on the expression of MTH2, OGG1, and MUTYH; shows a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies in vivo.

Name	N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide
Synonyms	N-Ethyl-4-[(3S)-3-methyl-4-morpholinyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide 1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]-

Description	BAY-707 is a highly potent, selective and substrate-competitive inhibitor of MTH1 (NUDT1) with IC50 of 2.3 nM; demonstrates high selectivity in an in-house kinase panel, and shows an overall favorable physicochemical profile and in vitro pharmacokinetic properties with high metabolic stability; demonstrates a superior cellular target engagement with an EC50 of 7.6 nM compared with TH588, increases the cellular thermal stabilization of MTH1 with no effect on the expression of MTH2, OGG1, and MUTYH; shows a clear lack of in vitro or in vivo anticancer efficacy either in mono- or in combination therapies in vivo.
References	References 1. Ellermann M, et al. ACS Chem Biol. 2017 Aug 18;12(8):1986-1992. View Related Products by Target DNA Repair Protein