219691-94-8
219691-94-8 structure
- Name: KB-141
- Chemical Name: KB-141
- CAS Number: 219691-94-8
- Molecular Formula: C17H16Cl2O4
- Molecular Weight: 355.212
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 15:38:51
- Modify Date: 2025-08-25 15:59:43
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KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα; selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats.
| Name | KB-141 |
|---|---|
| Synonyms |
Benzeneacetic acid, 3,5-dichloro-4-[4-hydroxy-3-(1-methylethyl)phenoxy]-
KB-141 3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid [3,5-Dichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]acetic acid |
| Description | KB-141 (KB141) is a potent, selective thyroid hormone receptor TRβ agonist (IC50=1.1 nM), binds to hTRβ with a 14-fold higher affinity than to hTRα; selectively reduces plasma cholesterol levels, also increases whole body oxygen consumption (MVO2) in both mice and rats. |
|---|---|
| References | References 1. Grover GJ, et al. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10067-72. 2. Johansson L, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10297-302. 3. Grover GJ, et al. Cardiovasc Drug Rev. 2005 Summer;23(2):133-48. Review. 4. Ye L, et al. J Med Chem. 2003 Apr 24;46(9):1580-8. View Related Products by Target Thyroid Hormone Receptor (THR) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 464.7±45.0 °C at 760 mmHg |
| Molecular Formula | C17H16Cl2O4 |
| Molecular Weight | 355.212 |
| Flash Point | 234.9±28.7 °C |
| Exact Mass | 354.042572 |
| LogP | 4.75 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.606 |