22200-69-7

22200-69-7 structure

Name: Seriniquinone
Chemical Name: seriniquinone
CAS Number: 22200-69-7
Molecular Formula: C₂₀H₈O₄S
Molecular Weight: 344.340
Create Date: 2020-01-12 19:38:52
Modify Date: 2024-01-17 19:27:57
A melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; demonstrates potent activity over a select set of tumor cell lines with particular selectivity toward melanoma cell lines; increases the cleavage of caspases 3, 7, and 9 and PARP in HCT-116 cells; causes an increasing level of DCD expression directly correlated with cell line selectivity,

Name	seriniquinone
Synonyms	seriniquinone Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone

Description	A melanoma-selective anticancer agent (IC50=30 nM, Malme-3M cell line), induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin; demonstrates potent activity over a select set of tumor cell lines with particular selectivity toward melanoma cell lines; increases the cleavage of caspases 3, 7, and 9 and PARP in HCT-116 cells; causes an increasing level of DCD expression directly correlated with cell line selectivity,
References	References 1. Trzoss L, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14687-92. 2. Matsuoka M, et al. J Heterocycl Chem. 1991;28(5):1445–1447. View Related Products by Target Other Targets