425666-42-8
425666-42-8 structure
- Name: TKDC
- Chemical Name: N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide
- CAS Number: 425666-42-8
- Molecular Formula: C18H19ClN2O3S
- Molecular Weight: 378.873
- Create Date: 2020-01-12 12:02:35
- Modify Date: 2024-01-09 21:09:29
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TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice.
| Name | N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide |
|---|---|
| Synonyms |
Methanesulfonamide, N-(4-chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]-
N-(4-chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide |
| Description | TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice. |
|---|---|
| References | References 1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378. View Related Products by Target Potassium Channel |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 588.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H19ClN2O3S |
| Molecular Weight | 378.873 |
| Flash Point | 309.5±32.9 °C |
| Exact Mass | 378.080475 |
| LogP | 3.45 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.640 |