446826-86-4
446826-86-4 structure
- Name: KIN-1400
- Chemical Name: KIN1400
- CAS Number: 446826-86-4
- Molecular Formula: C24H17F2N3O2S
- Molecular Weight: 449.473
- Catalog: Signaling Pathways Anti-infection HCV
- Create Date: 2020-01-11 18:07:49
- Modify Date: 2025-08-21 12:49:57
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A potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression; shows antiviral activity against a broad range of RNA viruses, including dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus), and Paramyxoviridae (respiratory syncytial virus, Nipah virus).
| Name | KIN1400 |
|---|---|
| Synonyms |
7-{(1,3-benzothiazol-2-ylamino)[4-(difluoromethoxy)phenyl]methyl}quinolin-8-ol
KIN1400 TCMDC-124379 8-Quinolinol, 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]- 7-{(1,3-Benzothiazol-2-ylamino)[4-(difluoromethoxy)phenyl]methyl}-8-quinolinol 7-[(2-benzothiazolylamino)[4-(difluoromethoxy)phenyl]methyl]-8-quinolinol MFCD02655498 |
| Description | A potent RIG-I-like receptor (RLR) agonist that triggers IRF3-dependent innate immune antiviral genes and IFN-β expression; shows antiviral activity against a broad range of RNA viruses, including dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus), and Paramyxoviridae (respiratory syncytial virus, Nipah virus). |
|---|---|
| References | References 1. Pattabhi S, et al. J Virol. 2015 Dec 16;90(5):2372-87. View Related Products by Target RIG-I-like Receptor (RLR) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 651.1±65.0 °C at 760 mmHg |
| Molecular Formula | C24H17F2N3O2S |
| Molecular Weight | 449.473 |
| Flash Point | 347.5±34.3 °C |
| Exact Mass | 449.100952 |
| LogP | 5.48 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.727 |