654080-03-2

654080-03-2 structure

Name: SK 216
Chemical Name: Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate
CAS Number: 654080-03-2
Molecular Formula: C₂₉H₂₉NO₆Na₂
Molecular Weight: 533.523
Create Date: 2020-01-12 07:47:28
Modify Date: 2024-01-05 17:35:58
SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM; reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model, also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.

Name	Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate
Synonyms	Propanedioic acid, 2-[5-[[6-[5-(1,1-dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-, sodium salt (1:2) Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate

Description	SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM; reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model, also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.
References	References 1. Masuda T, et al. Mol Cancer Ther. 2013 Nov;12(11):2378-88. 2. Mutoh M, et al. Carcinogenesis. 2008 Apr;29(4):824-9. 3. Takayama Y, et al. Cancer Res. 2016 Jun 1;76(11):3285-94. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1)