744270-00-6
744270-00-6 structure
- Name: ML116
- Chemical Name: 4-(4-Benzyl-1-piperidinyl)thieno[2,3-d]pyrimidine
- CAS Number: 744270-00-6
- Molecular Formula: C18H19N3S
- Molecular Weight: 309.429
- Create Date: 2020-01-11 18:52:50
- Modify Date: 2023-01-11 16:54:04
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A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM); inhibits transcription of the STAT3-regulated gene BCL3, sslectively induces loss of viability of breast cancer cell lines such as MDA-MB-468 cells.
| Name | 4-(4-Benzyl-1-piperidinyl)thieno[2,3-d]pyrimidine |
|---|---|
| Synonyms |
MFCD04535848
4-[4-(phenylmethyl)-1-piperidinyl]thieno[2,3-d]pyrimidine Thieno[2,3-d]pyrimidine, 4-[4-(phenylmethyl)-1-piperidinyl]- 4-benzyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine 4-(4-Benzyl-1-piperidinyl)thieno[2,3-d]pyrimidine |
| Description | A novel selective STAT3 inhibitor with IC50 of 4.2 uM, does not inhibit STAT1, STAT5, or NFkB signaling pathways (IC50>50 uM); inhibits transcription of the STAT3-regulated gene BCL3, sslectively induces loss of viability of breast cancer cell lines such as MDA-MB-468 cells. |
|---|---|
| References | References 1. Assi HH, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):458-69. 2. Madoux F, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target STAT |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 482.3±25.0 °C at 760 mmHg |
| Molecular Formula | C18H19N3S |
| Molecular Weight | 309.429 |
| Flash Point | 245.5±23.2 °C |
| Exact Mass | 309.129974 |
| LogP | 4.42 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.663 |