801227-82-7
801227-82-7 structure
- Name: SirReal1
- Chemical Name: N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetamide
- CAS Number: 801227-82-7
- Molecular Formula: C18H18N4OS2
- Molecular Weight: 370.492
- Create Date: 2020-01-12 11:42:27
- Modify Date: 2024-10-03 09:27:06
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A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM; displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM).
| Name | N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetamide |
|---|---|
| Synonyms |
N-(5-benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide
Acetamide, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-[5-(phenylmethyl)-2-thiazolyl]- N-(5-Benzyl-1,3-thiazol-2-yl)-2-[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetamide |
| Description | A novel potent, selective Sirt2 inhibitor with IC50 of 3.745 uM; displays no inhibitory activity against Sirt1 and Sirt 3 (IC50>100 uM). |
|---|---|
| References | References 1. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6. View Related Products by Target Sirtuin |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H18N4OS2 |
| Molecular Weight | 370.492 |
| Exact Mass | 370.092194 |
| LogP | 4.60 |
| Index of Refraction | 1.661 |