1025276-65-6
1025276-65-6 structure
- Name: NS-3-008 hydrochloride
- Chemical Name: 2-Benzyl-1-hexylguanidine
- CAS Number: 1025276-65-6
- Molecular Formula: C14H23N3
- Molecular Weight: 233.352
- Create Date: 2020-01-11 22:33:29
- Modify Date: 2024-01-01 19:19:48
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NS-3-008 hydrochloride is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD).
| Name | 2-Benzyl-1-hexylguanidine |
|---|---|
| Synonyms |
Guanidine, N-hexyl-N''-(phenylmethyl)-
2-Benzyl-1-hexylguanidine |
| Description | NS-3-008 hydrochloride is a novel small-molecule transcriptional inhibitor of G0s2 (G0/G1 switch 2) with IC50 of 2.25 uM; decreases levels of G0s2 and Ccl2 mRNA in the kidneys (5 mg/kg, p.o.); decreases the phosphorylation of Stat5 and p65 protein and suppresses renal inflammation in 5/6Nx mice, ameliorates renal dysfunction in mouse model of chronic kidney disease (CKD). |
|---|---|
| References | References 1. Matsunaga N, et al. EBioMedicine. 2016 Nov;13:262-273. View Related Products by Target Other Targets |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 356.0±35.0 °C at 760 mmHg |
| Molecular Formula | C14H23N3 |
| Molecular Weight | 233.352 |
| Flash Point | 169.1±25.9 °C |
| Exact Mass | 233.189194 |
| LogP | 3.78 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.528 |