1065110-62-4

1065110-62-4 structure

Name: PF-03246799
Chemical Name: 2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine
CAS Number: 1065110-62-4
Molecular Formula: C₁₅H₁₇N₃
Molecular Weight: 239.316
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2020-01-14 13:46:43
Modify Date: 2024-04-05 19:09:01
A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.

Name	2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine
Synonyms	MFCD20040357

Description	A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.
References	References 1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. 2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. View Related Products by Target 5-HT Receptor