1065110-62-4
1065110-62-4 structure
- Name: PF-03246799
- Chemical Name: 2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine
- CAS Number: 1065110-62-4
- Molecular Formula: C15H17N3
- Molecular Weight: 239.316
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-14 13:46:43
- Modify Date: 2024-04-05 19:09:01
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A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.
| Name | 2-Benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine |
|---|---|
| Synonyms | MFCD20040357 |
| Description | A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties. |
|---|---|
| References | References 1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. 2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. View Related Products by Target 5-HT Receptor |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 418.2±33.0 °C at 760 mmHg |
| Molecular Formula | C15H17N3 |
| Molecular Weight | 239.316 |
| Flash Point | 206.7±25.4 °C |
| Exact Mass | 239.142242 |
| LogP | 1.31 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.580 |