1092797-77-7
1092797-77-7 structure
- Name: SK 609
- Chemical Name: 4-(2-Chlorophenyl)-2-butanamine hydrochloride (1:1)
- CAS Number: 1092797-77-7
- Molecular Formula: C10H15Cl2N
- Molecular Weight: 220.139
- Create Date: 2020-01-19 19:23:42
- Modify Date: 2023-02-05 14:18:09
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SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation; reverses akinesia and reduces L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson's desease.
| Name | 4-(2-Chlorophenyl)-2-butanamine hydrochloride (1:1) |
|---|---|
| Synonyms |
Benzenepropanamine, 2-chloro-α-methyl-, hydrochloride (1:1)
4-(2-Chlorophenyl)-2-butanamine hydrochloride (1:1) |
| Description | SK609 (SK-609, ES609) is a potent, selective agonist of dopamine D3 receptor with a bias towards the G-protein-dependent pathway rather than recruiting β-arrestin-2 and an EC50 value of 113.9 nM for activation of ERK1/2 phosphorylation; reverses akinesia and reduces L-dopa-induced dyskinesia in a hemiparkinsonian rat model of Parkinson's desease. |
|---|---|
| References | References 1. Marshall CA, et al. Neuropharmacology. 2019 Jan 8. pii: S0028-3908(19)30002-4. 2. Xu W, et al. ACS Chem Neurosci. 2017 Mar 15;8(3):486-500. 3. Kuzhikandathil EV, et al. Pharm Res. 2012 Aug;29(8):2264-75. View Related Products by Target Dopamine Receptor |
| Molecular Formula | C10H15Cl2N |
|---|---|
| Molecular Weight | 220.139 |
| Exact Mass | 219.058151 |