1200493-78-2

1200493-78-2 structure

Name: Atabecestat
Chemical Name: atabecestat
CAS Number: 1200493-78-2
Molecular Formula: C₁₈H₁₄FN₅OS
Molecular Weight: 367.400
Catalog: Signaling Pathways Neuronal Signaling Beta-secretase
Create Date: 2020-01-11 18:48:25
Modify Date: 2024-09-25 22:15:47
Atabecestat (JNJ-54861911, JNJ54861911) is a novel potent, oral beta-secretase (BACE) inhibitor for treatment of Alzheimer's Disease.

Name	atabecestat
Synonyms	JNJ-54861911 N-{3-[(4S)-2-Amino-4-methyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-cyano-2-pyridinecarboxamide 2-Pyridinecarboxamide, N-[3-[(4S)-2-amino-4-methyl-4H-1,3-thiazin-4-yl]-4-fluorophenyl]-5-cyano- atabecestat

Description	Atabecestat (JNJ-54861911, JNJ54861911) is a novel potent, oral beta-secretase (BACE) inhibitor for treatment of Alzheimer's Disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	IC50: BACE1[1]
References	[1]. Timmers M, et al. Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor.Alzheimers Dement (N Y). 2016 Aug 24;2(3):202-212.