131068-23-0

131068-23-0 structure

Name: Hydrazinocurcumin
Chemical Name: hydrazinocurcumin
CAS Number: 131068-23-0
Molecular Formula: C₂₁H₂₀N₂O₄
Molecular Weight: 364.395
Create Date: 2020-01-11 18:51:56
Modify Date: 2024-01-11 18:34:21
Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets; suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis; inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.

Name	hydrazinocurcumin
Synonyms	hydrazinocurcumin (E)-3,5-bis[β-(4-hydroxy-3-methoxyphenyl)-ethenyl]-1H-pyrazole 4,4'-[1H-Pyrazole-3,5-diyldi(E)-2,1-ethenediyl]bis(2-methoxyphenol) Phenol, 4,4'-[1H-pyrazole-3,5-diyldi(E)-2,1-ethenediyl]bis[2-methoxy- 4,4'-[1H-Pyrazole-3,5-diyldi(E)ethene-2,1-diyl]bis(2-methoxyphenol)

Description	Hydrazinocurcumin is a synthetic curcumin derivative that inhibits the proliferation of bovine aortic endothelial cells (BAECs) with IC50 of 520 nM without cytotoxicity, inhibits STAT3 phosphorylation and downregulates an array of STAT3 downstream targets; suppresses cell proliferation, depresses cell migration and invasion, induces cell apoptosis; inhibits the cell cycle progression of colon cancer cells via antagonizing of Ca2+/calmodulin functions.
References	References 1. Shim JS, et al. Bioorg Med Chem. 2002 Sep;10(9):2987-92. 2. Shim JS, et al. Bioorg Med Chem. 2002 Aug;10(8):2439-44. 3. Wang X, et al. Int J Oncol. 2012 Apr;40(4):1189-95. View Related Products by Target STAT