1330624-42-4
1330624-42-4 structure
- Name: VU0418506
- Chemical Name: N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine
- CAS Number: 1330624-42-4
- Molecular Formula: C12H8ClFN4
- Molecular Weight: 262.670
- Create Date: 2020-01-12 11:36:00
- Modify Date: 2023-01-17 20:28:19
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VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4); displays selectivity versus the Group I and Group II mGlu receptors and against mGlu7 and mGlu8; does not potentiate agonist-induced activity when mGlu2 and mGlu4 are heterodimerized; VU0418506 is clean against a panel of ion channels associated with cardiac toxicity and it negative in a mini-AMES assay with and without S9.
| Name | N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine |
|---|---|
| Synonyms |
1H-Pyrazolo[4,3-b]pyridin-3-amine, N-(3-chloro-4-fluorophenyl)-
MFCD30481312 N-(3-Chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine |
| Description | VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4); displays selectivity versus the Group I and Group II mGlu receptors and against mGlu7 and mGlu8; does not potentiate agonist-induced activity when mGlu2 and mGlu4 are heterodimerized; VU0418506 is clean against a panel of ion channels associated with cardiac toxicity and it negative in a mini-AMES assay with and without S9. |
|---|---|
| References | References 1. Engers DW, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1192-200. 2. Niswender CM, et al. ACS Chem Neurosci. 2016 Sep 21;7(9):1201-11. View Related Products by Target mGluR |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 467.0±45.0 °C at 760 mmHg |
| Molecular Formula | C12H8ClFN4 |
| Molecular Weight | 262.670 |
| Flash Point | 236.2±28.7 °C |
| Exact Mass | 262.042145 |
| LogP | 4.47 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.743 |