1330781-04-8
1330781-04-8 structure
- Name: Cdc7 inhibitor 7c
- Chemical Name: 6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
- CAS Number: 1330781-04-8
- Molecular Formula: C15H17N5OS
- Molecular Weight: 315.393
- Create Date: 2020-01-12 11:29:58
- Modify Date: 2024-01-27 11:44:11
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A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition.
| Name | 6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one |
|---|---|
| Synonyms |
6-(3-Methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)thieno[3,2-d]pyrimidin-4(3H)-one
Thieno[3,2-d]pyrimidin-4(3H)-one, 6-(3-methyl-1H-pyrazol-4-yl)-2-(1-pyrrolidinylmethyl)- |
| Description | A highly potent, selective and time-dependent Cdc7 kinase inhibitor with IC50 of 0.7 nM with slow dissociation property, with 200-fold and >14,000-fold selectivity over CDK2 and ROCK1, respectively; exhibits significant time-dependent Cdc7 inhibition with slow dissociation kinetics, cellular pharmacodynamic (PD) effects, and COLO205 growth inhibition. |
|---|---|
| References | References 1. Kurasawa O, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3658-3670. View Related Products by Target Cyclin-dependent Kinase (CDK) |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C15H17N5OS |
| Molecular Weight | 315.393 |
| Exact Mass | 315.115387 |
| LogP | 1.71 |
| Index of Refraction | 1.805 |