133847-06-0

133847-06-0 structure

Name: YU142670
Chemical Name: YU142670
CAS Number: 133847-06-0
Molecular Formula: C₈H₅N₅S
Molecular Weight: 203.224
Create Date: 2020-01-12 06:34:58
Modify Date: 2025-08-26 16:54:11
YU142670 is a highly specific, soluble OCRL/INPP5B inhibitor that directly interacts with the catalytic domain of INPP5B; induces enhanced actin polymerization and ruffle activity at the plasma membrane, increases the levels of PI(4,5)P2 in mouse embryonic fibroblasts or human dermal fibroblasts and inhibits the activity of over-expressed human OCRL in Cos-7 cells.

Name	YU142670
Synonyms	YU142670 3-(4-pyridinyl)-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole 3-(4-Pyridinyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 3-(Pyridin-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole MFCD06590438 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole, 3-(4-pyridinyl)-

Description	YU142670 is a highly specific, soluble OCRL/INPP5B inhibitor that directly interacts with the catalytic domain of INPP5B; induces enhanced actin polymerization and ruffle activity at the plasma membrane, increases the levels of PI(4,5)P2 in mouse embryonic fibroblasts or human dermal fibroblasts and inhibits the activity of over-expressed human OCRL in Cos-7 cells.
References	References 1. Pirruccello M, et al. ACS Chem Biol. 2014 Jun 20;9(6):1359-68. View Related Products by Target Protein Phosphatase/PTP