1345410-31-2
1345410-31-2 structure
- Name: CK-2127107
- Chemical Name: Reldesemtiv
- CAS Number: 1345410-31-2
- Molecular Formula: C19H18F2N6O
- Molecular Weight: 384.383
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-01-12 11:27:50
- Modify Date: 2024-01-08 11:53:59
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CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats. Spinal Muscular Atrophy (SMA) Phase 2 Clinical
| Name | Reldesemtiv |
|---|---|
| Synonyms |
Reldesemtiv
1-[2-({[trans-3-Fluoro-1-(3-fluoro-2-pyridinyl)cyclobutyl]methyl}amino)-5-pyrimidinyl]-1H-pyrrole-3-carboxamide 1H-Pyrrole-3-carboxamide, 1-[2-[[[trans-3-fluoro-1-(3-fluoro-2-pyridinyl)cyclobutyl]methyl]amino]-5-pyrimidinyl]- |
| Description | CK-2127107(CK-107, Reldesemtiv) is a novel orally active fast skeletal troponin activator, selectively activates fast skeletal myofibrils with EC50 of 3.4 uM; has no effect on slow skeletal or cardiac myofibrils; significantly improves rotarod performance in exercise-intolerant LAD-HF rats. Spinal Muscular Atrophy (SMA) Phase 2 Clinical |
|---|---|
| References | References 1. Hwee DT, et al. J Pharmacol Exp Ther. 2015 Apr;353(1):159-68. 2. Calder AN, et al. J Med Chem. 2016 Nov 23;59(22):10067-10083. View Related Products by Target Other Targets Spinal Muscular Atrophy (SMA) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.4±65.0 °C at 760 mmHg |
| Molecular Formula | C19H18F2N6O |
| Molecular Weight | 384.383 |
| Flash Point | 342.3±34.3 °C |
| Exact Mass | 384.151001 |
| LogP | 0.71 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.691 |