1354955-67-1
1354955-67-1 structure
- Name: GNE-293
- Chemical Name: 8-{[1-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-3-azetidinyl]oxy}-2-(2-isopropyl-1H-benzimidazol-1-yl)-9-methyl-6-(4-morpholinyl)-9H-purine
- CAS Number: 1354955-67-1
- Molecular Formula: C28H36N8O4S
- Molecular Weight: 580.702
- Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
- Create Date: 2020-01-19 22:57:56
- Modify Date: 2024-01-14 12:28:49
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GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively; exhibits excellent potency in human whole blood (HWB) assay (CD69 HWB IC50=4.38 nM); possesses favorable pharmacokinetic properties and orally bioavailable.
| Name | 8-{[1-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-3-azetidinyl]oxy}-2-(2-isopropyl-1H-benzimidazol-1-yl)-9-methyl-6-(4-morpholinyl)-9H-purine |
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| Synonyms |
9H-Purine, 9-methyl-2-[2-(1-methylethyl)-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-8-[[1-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-3-azetidinyl]oxy]-
8-{[1-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-3-azetidinyl]oxy}-2-(2-isopropyl-1H-benzimidazol-1-yl)-9-methyl-6-(4-morpholinyl)-9H-purine |
| Description | GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively; exhibits excellent potency in human whole blood (HWB) assay (CD69 HWB IC50=4.38 nM); possesses favorable pharmacokinetic properties and orally bioavailable. |
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| References | References 1. Safina BS, et al. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4953-9. View Related Products by Target PI3K |
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 853.5±75.0 °C at 760 mmHg |
| Molecular Formula | C28H36N8O4S |
| Molecular Weight | 580.702 |
| Flash Point | 470.0±37.1 °C |
| Exact Mass | 580.257996 |
| LogP | 1.20 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.755 |