1362911-19-0

1362911-19-0 structure

Name: proTAME
Chemical Name: Methyl N2-[(4-methylphenyl)sulfonyl]-N5-(2,6,10,14-tetraoxo-1,15-diphenyl-3,5,11,13-tetraoxa-7,9-diazapentadecan-8-ylidene)-L-ornithinate
CAS Number: 1362911-19-0
Molecular Formula: C₃₄H₃₈N₄O₁₂S
Molecular Weight: 726.750
Catalog: Signaling Pathways Cell Cycle/DNA Damage APC
Create Date: 2020-01-12 01:06:50
Modify Date: 2024-04-05 15:18:17
proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20); arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC); efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents.

Name	Methyl N2-[(4-methylphenyl)sulfonyl]-N5-(2,6,10,14-tetraoxo-1,15-diphenyl-3,5,11,13-tetraoxa-7,9-diazapentadecan-8-ylidene)-L-ornithinate
Synonyms	L-Ornithine, N5-[bis[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]methylene]-N2-[(4-methylphenyl)sulfonyl]-, methyl ester Methyl N2-[(4-methylphenyl)sulfonyl]-N5-(2,6,10,14-tetraoxo-1,15-diphenyl-3,5,11,13-tetraoxa-7,9-diazapentadecan-8-ylidene)-L-ornithinate

Description	proTAME is a cell permeable prodrug of TAME, which is an anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20); arrests cells in metaphase without perturbing the spindle, but is dependent on the spindle assembly checkpoint (SAC); efficiently targets osteosarcoma in vitro combined with chemotherapeutic agents.
References	References 1. Zeng X, et al. Cancer Cell. 2010 Oct 19;18(4):382-95. 2. Giovinazzi S, et al. Cell Cycle. 2013 Aug 15;12(16):2598-607. 3. Hu K, et al. Oncotarget. 2014 May 30;5(10):3088-100. View Related Products by Target E3 Ubiquitin Ligase