1394808-82-2

1394808-82-2 structure

Name: SUVN-G3031
Chemical Name: Suvn-G3031
CAS Number: 1394808-82-2
Molecular Formula: C₂₁H₃₁N₃O₃
Molecular Weight: 373.489
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2020-01-12 11:53:02
Modify Date: 2024-01-13 18:48:50
SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical

Name	Suvn-G3031
Synonyms	N-{4-[(1-Cyclobutyl-4-piperidinyl)oxy]phenyl}-2-(4-morpholinyl)acetamide 4-Morpholineacetamide, N-[4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl]- Suvn-G3031

Description	SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R); exhibited an IC50 of 20 nM with progressive inhibition of (R)-α-methylhistamine (0.03 µM) induced agonist activity in [35S]-GTPγS binding assay using CHO-K1 cells expressing human H3R membranes; reverses (R)-α-methylhistamine induced dipsogenia in vivo. Parkinson Disease Phase 1 Clinical
References	References 1. Nirogi R, et al. J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01280. View Related Products by Target Histamine Receptor Parkinson Disease