1451994-10-7

1451994-10-7 structure

Name: VU 0467485
Chemical Name: 5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
CAS Number: 1451994-10-7
Molecular Formula: C₁₇H₁₇FN₄O₂S
Molecular Weight: 360.406
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2020-01-11 17:39:58
Modify Date: 2024-02-01 11:41:06
VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4); possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia.

Name	5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide
Synonyms	5-Amino-N-(3-fluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide Thieno[2,3-c]pyridazine-6-carboxamide, 5-amino-N-[(3-fluoro-4-methoxyphenyl)methyl]-3,4-dimethyl-

Description	VU0467485 (VU-0467485, AZ13713945) is potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator with EC50 of 78.8 nM (hM4); possesses robust in vitro M4 PAM potency across species and in vivo efficacy in preclinical models of schizophrenia.
References	References 1. Wood MR, et al. ACS Med Chem Lett. 2016 Dec 16;8(2):233-238. 2. Melancon BJ, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2296-2301. 3. Deng X, et al. ChemMedChem. 2018 Dec 27. doi: 10.1002/cmdc.201800710. View Related Products by Target mAChR