376616-73-8

376616-73-8 structure

Name: ZQ 16
Chemical Name: ZQ-16
CAS Number: 376616-73-8
Molecular Formula: C₁₀H₁₆N₂O₂S
Molecular Weight: 228.311
Catalog: Signaling Pathways GPCR/G Protein GPR84
Create Date: 2020-01-11 19:58:57
Modify Date: 2024-01-30 14:39:00
A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.

Name	ZQ-16
Synonyms	2-(Hexylsulfanyl)-6-hydroxy-4(3H)-pyrimidinone 2-(Hexylsulfanyl)-6-hydroxypyrimidin-4(3H)-one ZQ-16 MFCD00475645 4(3H)-Pyrimidinone, 2-(hexylthio)-6-hydroxy- 2-(hexylthio)-6-hydroxy-4(3H)-pyrimidinone

Description	A novel potent and selective agonist of GPR84 that induces calcium response with EC50 of 0.213 uM; does not evoke calcium responses in HEK293 cells expressing other FFARs, including GPR40, GPR41, GPR119, and GPR120; increases in intracellular calcium concentrations in HEK293/Gα16/GPR84 cells with EC50 of 1.01 uM; activates several GPR84-mediated signaling pathways, including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of ERK1/2, receptor desensitization and internalization, and receptor-β-arrestin interaction; reduces forskolin-stimulated cAMP accumulation in HEK293 cells with EC50 of 0.134 uM.
References	References 1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44. 2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. View Related Products by Target Free Fatty Acid Receptor (FFAR)