656222-54-7
656222-54-7 structure
- Name: iKIX1
- Chemical Name: iKIX1
- CAS Number: 656222-54-7
- Molecular Formula: C10H8Cl2N4OS
- Molecular Weight: 303.168
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2020-01-11 12:35:55
- Modify Date: 2023-01-11 17:06:33
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A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease.
| Name | iKIX1 |
|---|---|
| Synonyms |
2-(Cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazinecarbothioamide
3-[(2-Cyanoacetyl)amino]-1-(3,4-dichlorophenyl)thiourea MFCD00119122 iKIX1 2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide |
| Description | A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease. |
|---|---|
| References | References 1. Nishikawa JL, et al. Nature. 2016 Feb 25;530(7591):485-9. View Related Products by Target Fungal |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C10H8Cl2N4OS |
| Molecular Weight | 303.168 |
| Exact Mass | 301.979584 |
| LogP | 2.26 |
| Index of Refraction | 1.681 |