656222-54-7

656222-54-7 structure

Name: iKIX1
Chemical Name: iKIX1
CAS Number: 656222-54-7
Molecular Formula: C₁₀H₈Cl₂N₄OS
Molecular Weight: 303.168
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2020-01-11 12:35:55
Modify Date: 2025-06-01 10:58:45
A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease.

Name	iKIX1
Synonyms	2-(Cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazinecarbothioamide 3-[(2-Cyanoacetyl)amino]-1-(3,4-dichlorophenyl)thiourea MFCD00119122 iKIX1 2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide

Description	A small-molecule inhibitor of the interaction of the C. glabrata Pdr1 activation domain with the C. glabrata Gal11A KIX domain with Ki of 18 uM; blocks Gal11/Med15 recruitment and inhibits Pdr1-dependent gene activation and re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in animal models for disseminated and urinary tract C. glabrata infection; a novel therapeutic strategy in fungal infectious disease.
References	References 1. Nishikawa JL, et al. Nature. 2016 Feb 25;530(7591):485-9. View Related Products by Target Fungal