66171-75-3
66171-75-3 structure
- Name: SirT1 enhancer A03
- Chemical Name: (S)-alaproclate
- CAS Number: 66171-75-3
- Molecular Formula: C13H18ClNO2
- Molecular Weight: 255.740
- Create Date: 2020-01-11 19:04:53
- Modify Date: 2025-09-10 11:41:05
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SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity
| Name | (S)-alaproclate |
|---|---|
| Synonyms |
L-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester
(S)-alaproclate DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester 1-(4-chlorophenyl)-2-methylpropan-2-yl L-alaninate 1-(4-Chlorophenyl)-2-methyl-2-propanyl L-alaninate |
| Description | SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM); increases SirT1 levels in the hippocampus of Alzheimer's disease (AD) model mice and elicits cognitive improvement while inducing no observed toxicity |
|---|---|
| References | References 1. Campagna J, et al. Sci Rep. 2018 Dec 4;8(1):17574. View Related Products by Target Sirtuin |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 335.1±22.0 °C at 760 mmHg |
| Molecular Formula | C13H18ClNO2 |
| Molecular Weight | 255.740 |
| Flash Point | 156.5±22.3 °C |
| Exact Mass | 255.102600 |
| LogP | 2.93 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.528 |