748778-73-6

748778-73-6 structure

Name: YC-001
Chemical Name: 4-(5-Chloro-2-thienyl)-3-(2-thienyl)-2(5H)-furanone
CAS Number: 748778-73-6
Molecular Formula: C₁₂H₇ClO₂S₂
Molecular Weight: 282.766
Catalog: Research Areas Others
Create Date: 2020-01-11 19:42:57
Modify Date: 2024-01-01 18:44:09
YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells; demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity; binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant; YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration.

Name	4-(5-Chloro-2-thienyl)-3-(2-thienyl)-2(5H)-furanone
Synonyms	4-(5-Chloro-2-thienyl)-3-(2-thienyl)-2(5H)-furanone 2(5H)-Furanone, 4-(5-chloro-2-thienyl)-3-(2-thienyl)- MFCD03948015

Description	YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells; demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity; binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant; YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration.
References	References 1. Chen Y, et al. Nat Commun. 2018 May 17;9(1):1976. View Related Products by Target Other Targets