748786-57-4
748786-57-4 structure
- Name: TLSC702
- Chemical Name: (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid
- CAS Number: 748786-57-4
- Molecular Formula: C18H15NO3S
- Molecular Weight: 325.382
- Create Date: 2020-01-11 16:21:53
- Modify Date: 2023-01-16 08:52:37
-
TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells.
| Name | (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid |
|---|---|
| Synonyms |
MFCD06660558
2-Benzothiazolepropanoic acid, β-[(4-methoxyphenyl)methylene]-, (βZ)- (3Z)-3-(1,3-Benzothiazol-2-yl)-4-(4-methoxyphenyl)-3-butenoic acid |
| Description | TLSC702 is a novel potent inhibitor of human glyoxalase I (hGLO I) with IC50 of 2.0 uM; inhibits the proliferation of human leukemia HL-60 cells and induces apoptosis in a dose-dependent manner; more significantly inhibits the proliferation of human lung cancer NCI-H522 cells, which highly express GLO I, than that of GLO I lower-expressing human lung cancer NCI-H460 cells. |
|---|---|
| References | References 1. Takasawa R, et al. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4337-42. 2. Takasawa R, et al. Biol Pharm Bull. 2016;39(5):869-73. 3. Shimada N, et al. Arch Biochem Biophys. 2018 Jan 15;638:1-7. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 547.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H15NO3S |
| Molecular Weight | 325.382 |
| Flash Point | 284.7±32.9 °C |
| Exact Mass | 325.077271 |
| LogP | 5.44 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.696 |