813447-40-4
813447-40-4 structure
- Name: PF-184298
- Chemical Name: PF-184298
- CAS Number: 813447-40-4
- Molecular Formula: C15H20Cl2N2O
- Molecular Weight: 315.238
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-01-11 08:19:54
- Modify Date: 2024-02-19 17:43:47
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PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively; displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM); possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space.
| Name | PF-184298 |
|---|---|
| Synonyms |
PZR8DT7L3O
PF-184298 Benzamide, 2,3-dichloro-N-(2-methylpropyl)-N-[(3S)-3-pyrrolidinyl]- 2,3-Dichloro-N-isobutyl-N-[(3S)-3-pyrrolidinyl]benzamide |
| Description | PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively; displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM); possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space. |
|---|---|
| References | References 1. Wakenhut F, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):772. 2. Harrison A, et al. Xenobiotica. 2012 Jan;42(1):57-74. View Related Products by Target Monoamine Transporter |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 461.9±45.0 °C at 760 mmHg |
| Molecular Formula | C15H20Cl2N2O |
| Molecular Weight | 315.238 |
| Flash Point | 233.1±28.7 °C |
| Exact Mass | 314.095276 |
| LogP | 3.14 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.574 |