813447-40-4

813447-40-4 structure

Name: PF-184298
Chemical Name: PF-184298
CAS Number: 813447-40-4
Molecular Formula: C₁₅H₂₀Cl₂N₂O
Molecular Weight: 315.238
Catalog: Research Areas Cardiovascular Disease
Create Date: 2020-01-11 08:19:54
Modify Date: 2024-02-19 17:43:47
PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively; displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM); possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space.

Name	PF-184298
Synonyms	PZR8DT7L3O PF-184298 Benzamide, 2,3-dichloro-N-(2-methylpropyl)-N-[(3S)-3-pyrrolidinyl]- 2,3-Dichloro-N-isobutyl-N-[(3S)-3-pyrrolidinyl]benzamide

Description	PF-184298 is a potent, selective dual serotonin and noradrenaline monoamine reuptake inhibitor (SNRI) with IC50 of 6 nM and 21 nM, respectively; displays good selectivity over dopamine reuptake inhibition (DRI) (IC50=544 nM); possesses good in vitro metabolic stability, weak CYP inhibition and drug-like physicochemical properties consistent with CNS target space.
References	References 1. Wakenhut F, et al. Bioorg Med Chem Lett. 2010 Jan 15;20(2):772. 2. Harrison A, et al. Xenobiotica. 2012 Jan;42(1):57-74. View Related Products by Target Monoamine Transporter