883958-36-9
883958-36-9 structure
- Name: MLS1082
- Chemical Name: 2-Cyclohexyl-10-methyl-3-phenyl-3H,10H-pyrimido[4,5-b]quinoline-4,5-dione
- CAS Number: 883958-36-9
- Molecular Formula: C24H23N3O2
- Molecular Weight: 385.458
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2020-01-11 23:17:50
- Modify Date: 2024-02-03 19:44:56
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MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies.
| Name | 2-Cyclohexyl-10-methyl-3-phenyl-3H,10H-pyrimido[4,5-b]quinoline-4,5-dione |
|---|---|
| Synonyms |
Pyrimido[4,5-b]quinoline-4,5(3H,10H)-dione, 2-cyclohexyl-10-methyl-3-phenyl-
2-Cyclohexyl-10-methyl-3-phenylpyrimido[4,5-b]quinoline-4,5(3H,10H)-dione 2-Cyclohexyl-10-methyl-3-phenyl-3H,10H-pyrimido[4,5-b]quinoline-4,5-dione |
| Description | MLS1082 is a novel positive allosteric modulator of the D1 dopamine receptor, potentiatse dopamine-stimulated G-protein- and β-arrestin-mediated signaling and increase the affinity of dopamine for the D1 receptor with low micromolar potencies. |
|---|---|
| References | References 1. Luderman KD, et al. Mol Pharmacol. 2018 Aug 1. pii: mol.118.113175. View Related Products by Target Dopamine Receptor |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 520.1±60.0 °C at 760 mmHg |
| Molecular Formula | C24H23N3O2 |
| Molecular Weight | 385.458 |
| Flash Point | 268.4±32.9 °C |
| Exact Mass | 385.179016 |
| LogP | 2.78 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.688 |