900897-56-5

900897-56-5 structure

Name: KRAS inhibitor 11
Chemical Name: 2-[4-(2-Methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-yl)-1-piperazinyl]ethanol
CAS Number: 900897-56-5
Molecular Formula: C₂₅H₂₇N₅O
Molecular Weight: 413.515
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2020-01-11 19:12:55
Modify Date: 2025-08-25 12:02:29
KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM; binds to activated KRAS with sub-micromolar affinity and disrupts effector binding, thereby inhibiting KRAS signaling and cancer cell growth; dose-dependently decreases both p-ERK and p-cRaf levels in BHK cells expressing KRASG12D and KRASG12V, suggesting inhibition of RAS signaling via the MAPK pathway.

Name	2-[4-(2-Methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-yl)-1-piperazinyl]ethanol
Synonyms	2-[4-(2-Methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-yl)-1-piperazinyl]ethanol 1-Piperazineethanol, 4-(2-methyl-3,5-diphenylpyrazolo[1,5-a]pyrimidin-7-yl)-

Description	KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM; binds to activated KRAS with sub-micromolar affinity and disrupts effector binding, thereby inhibiting KRAS signaling and cancer cell growth; dose-dependently decreases both p-ERK and p-cRaf levels in BHK cells expressing KRASG12D and KRASG12V, suggesting inhibition of RAS signaling via the MAPK pathway.
References	References 1. McCarthy MJ, et al. ACS Omega. 2019 Feb 28;4(2):2921-2930. View Related Products by Target Ras