928659-17-0

928659-17-0 structure

Name: Triazavirin
Chemical Name: Riamilovir Sodium Dihydrate
CAS Number: 928659-17-0
Molecular Formula: C₅H₇N₆NaO₅S
Molecular Weight: 286.201
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2020-01-11 22:07:01
Modify Date: 2024-01-02 11:47:48
Triazavirin (Riamilovir sodium dihydrate) is a broad-spectrum antiviral agent targeting influenza viruses, lassa virus, TBEV and Ebola virus; suppresses the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and protects mice from death caused by type A and B influenza viruses.

Name	Riamilovir Sodium Dihydrate
Synonyms	Riamilovir Sodium Dihydrate Sodium 7-(methylsulfanyl)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-1-ide hydrate (1:1:2) [1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(1H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate (1:1:2)

Description	Triazavirin (Riamilovir sodium dihydrate) is a broad-spectrum antiviral agent targeting influenza viruses, lassa virus, TBEV and Ebola virus; suppresses the replication of influenza virus in cell culture and in chicken chorioallantoic membranes, and protects mice from death caused by type A and B influenza viruses.
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Target	Nucleoside analogue; Influenza virus[1]
In Vitro	The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin) by accumulation in the SKEV cell culture[2].
In Vivo	The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed[3].
References	[1]. Kozhikhova KV, et al. Preparation of chitosan-coated liposomes as a novel carrier system for the antiviral drug Triazavirin. Pharm Dev Technol. 2018 Apr;23(4):334-342. [2]. Loginova SIa, et al. Investigation of Triazavirin antiviral activity against tick-borne encephalitis pathogen in cell culture. Antibiot Khimioter. 2014;59(1-2):3-5. [3]. Loginova SY, et al. Investigation of Therapeutic Efficacy of Triazavirin Against Experimental Forest-Spring Encephalitis on Albino Mice. Antibiot Khimioter. 2015;60(7-8):11-3.

Molecular Formula	C₅H₇N₆NaO₅S
Molecular Weight	286.201
Exact Mass	286.009644

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