937782-05-3
937782-05-3 structure
- Name: Difamilast
- Chemical Name: Difamilast
- CAS Number: 937782-05-3
- Molecular Formula: 3H24F2N2O5
- Molecular Weight: 446.444
- Create Date: 2020-01-11 19:36:43
- Modify Date: 2025-08-24 10:17:29
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Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). Dermatitis Phase 2 Clinical
| Name | Difamilast |
|---|---|
| Synonyms |
Difamilast
N-({2-[4-(Difluoromethoxy)-3-isopropoxyphenyl]-1,3-oxazol-4-yl}methyl)-2-ethoxybenzamide Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy- |
| Description | Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). Dermatitis Phase 2 Clinical |
|---|---|
| References | References 1. Hanifin JM, et al. J Am Acad Dermatol. 2016 Aug;75(2):297-305. View Related Products by Target Phosphodiesterase (PDE) Dermatitis |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | 3H24F2N2O5 |
| Molecular Weight | 446.444 |
| Exact Mass | 446.165314 |
| LogP | 4.73 |
| Index of Refraction | 1.534 |