1010731-97-1
1010731-97-1 structure
- Name: MLN 3897
- Chemical Name: MLN 3897
- CAS Number: 1010731-97-1
- Molecular Formula: C32H39ClN2O3
- Molecular Weight: 535.125
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2024-01-06 12:02:24
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MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5; inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-fos signaling, inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-Fos signaling; demonstrates potential for the treatment of multiple sclerosis and rheumatoid arthritis. Multiple Sclerosis Phase 1 Discontinued
| Name | MLN 3897 |
|---|
| Description | MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5; inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-fos signaling, inhibits osteoclastogenesis and OC activity by impairing multinucleation and by down-regulation of c-Fos signaling; demonstrates potential for the treatment of multiple sclerosis and rheumatoid arthritis. Multiple Sclerosis Phase 1 Discontinued |
|---|---|
| References | References 1. Gilchrist A, et al. Br J Pharmacol. 2014 Nov;171(22):5127-38. 2. Vallet S, et al. Blood. 2007 Nov 15;110(10):3744-52. 3. Lu C, et al. J Pharmacol Exp Ther. 2010 Feb;332(2):562-8. 4. Vergunst CE, et al. Arthritis Rheum. 2009 Dec;60(12):3572-81. View Related Products by Target Chemokine Receptor (CCR and CXCR) Multiple Sclerosis |
| Molecular Formula | C32H39ClN2O3 |
|---|---|
| Molecular Weight | 535.125 |