1222104-37-1
1222104-37-1 structure
- Name: DS-7423
- Chemical Name: DS-7423
- CAS Number: 1222104-37-1
- Molecular Formula: C22H27F3N10O2
- Molecular Weight: 520.52
- Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
- Create Date: 2020-01-20 18:58:57
- Modify Date: 2024-01-11 16:46:33
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DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models. Solid Tumors Phase 1 Discontinued
| Name | DS-7423 |
|---|
| Description | DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models. Solid Tumors Phase 1 Discontinued |
|---|---|
| References | References 1. Koul D, et al. Oncotarget. 2017 Mar 28;8(13):21741-21753. 2. Kashiyama T, et al. PLoS One. 2014 Feb 4;9(2):e87220. View Related Products by Target PI3K Solid Tumors |
| Molecular Formula | C22H27F3N10O2 |
|---|---|
| Molecular Weight | 520.52 |