1222104-37-1

1222104-37-1 structure

Name: DS-7423
Chemical Name: DS-7423
CAS Number: 1222104-37-1
Molecular Formula: C₂₂H₂₇F₃N₁₀O₂
Molecular Weight: 520.52
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2020-01-20 18:58:57
Modify Date: 2024-01-11 16:46:33
DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models. Solid Tumors Phase 1 Discontinued

Name	DS-7423

Description	DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models. Solid Tumors Phase 1 Discontinued
References	References 1. Koul D, et al. Oncotarget. 2017 Mar 28;8(13):21741-21753. 2. Kashiyama T, et al. PLoS One. 2014 Feb 4;9(2):e87220. View Related Products by Target PI3K Solid Tumors

Molecular Formula	C₂₂H₂₇F₃N₁₀O₂
Molecular Weight	520.52