1834571-82-2
1834571-82-2 structure
- Name: AC-4-130
- Chemical Name: AC-4-130
- CAS Number: 1834571-82-2
- Molecular Formula: C37H36ClF5N2O5S
- Molecular Weight: 751.206
- Catalog: Signaling Pathways JAK/STAT Signaling STAT
- Create Date: 2020-01-12 17:10:23
- Modify Date: 2024-01-05 20:28:05
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AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo.
| Name | AC-4-130 |
|---|
| Description | AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3; disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription; substantially impairs the proliferation and clonogenic growth of human AML cell lines and primary FLT3-ITD+ AML patient cells in vitro and in vivo; synergistically increases the cytotoxicity of the JAK1/2 inhibitor Ruxolitinib and the p300/pCAF inhibitor Garcinol in vivo. |
|---|---|
| References | References 1. Wingelhofer B, et al. Leukemia. 2018 Feb 2. doi: 10.1038/s41375-017-0005-9. View Related Products by Target STAT |
| Molecular Formula | C37H36ClF5N2O5S |
|---|---|
| Molecular Weight | 751.206 |