2138321-18-1
2138321-18-1 structure
- Name: proMMP9-IN-3c
- Chemical Name: proMMP9-IN-3c
- CAS Number: 2138321-18-1
- Molecular Formula: C18H20FN3O2S
- Molecular Weight: 361.435
- Create Date: 2020-01-11 18:20:49
- Modify Date: 2024-04-09 08:44:33
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proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM; disrupts MMP-9 homodimerization, prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in dissociation of EGFR; decreases phosphorylation of Src and its downstream target proteins FAK and paxillin in cancer cells; blocks cancer cell invasion of the basement membrane and reduces angiogenesis at 500 nM.
| Name | proMMP9-IN-3c |
|---|
| Description | proMMP9-IN-3c is a potent and specific inhibitor of the hemopexin-like domain of MMP-9 (proMMP-9) with Kd of 320 nM; disrupts MMP-9 homodimerization, prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in dissociation of EGFR; decreases phosphorylation of Src and its downstream target proteins FAK and paxillin in cancer cells; blocks cancer cell invasion of the basement membrane and reduces angiogenesis at 500 nM. |
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| References | References 1. Alford VM, et al. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Molecular Formula | C18H20FN3O2S |
|---|---|
| Molecular Weight | 361.435 |