422281-45-6
422281-45-6 structure
- Name: SW-083688
- Chemical Name: SW-083688
- CAS Number: 422281-45-6
- Molecular Formula: C23H25N3O5S
- Molecular Weight: 455.529
- Catalog: Signaling Pathways MAPK/ERK Pathway MAP3K
- Create Date: 2020-01-11 21:41:50
- Modify Date: 2024-04-02 19:43:29
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SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM; increases the abundance of p62 and inhibits autophagy; TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target.
| Name | SW-083688 |
|---|
| Description | SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM; increases the abundance of p62 and inhibits autophagy; TAOK2 is an activator of p38 MAP kinase cascade that is up-regulated in response to environmental stresses, and a potential cancer therapeutic target. |
|---|---|
| References | References 1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7. View Related Products by Target MEKK (MAP3K) |
| Molecular Formula | C23H25N3O5S |
|---|---|
| Molecular Weight | 455.529 |