1026307-65-2
1026307-65-2 structure
- Name: MK-1
- Chemical Name: MK-1
- CAS Number: 1026307-65-2
- Molecular Formula: C30H26F3N7O2
- Molecular Weight: 573.58
- Create Date: 2020-01-11 19:52:50
- Modify Date: 2023-01-21 18:43:21
-
MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation; a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells, also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR.
| Name | MK-1 |
|---|
| Description | MK1 is a small molecule inducer of megakaryopoiesis (EC90=750 nM) that induces the differentiation of common myeloid progenitors (CMP) to megakaryocytes, does not adversely affect erythrocyte differentiation; a PDGFR inhibitor that inhibits PDGF-CC-mediated PDGFR phosphorylation in U138-malignant glioma cells, also inhibits the PDGF-CC-induced phosphorylation of PLCγ1, a major downstream target of PDGFR. |
|---|---|
| References | References 1. Boitano AE, et al. Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14019-23. View Related Products by Target PDGFR |
| Molecular Formula | C30H26F3N7O2 |
|---|---|
| Molecular Weight | 573.58 |