1042735-18-1
1042735-18-1 structure
- Name: ABC 1183
- Chemical Name: ABC 1183
- CAS Number: 1042735-18-1
- Molecular Formula: C18H14N4OS
- Molecular Weight: 334.397
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2020-01-11 17:09:49
- Modify Date: 2024-01-16 10:14:47
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ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modulates oncogenic signaling through changes in GSK3, GS and β-catenin phosphorylation and MCL1 expression; suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms without organ or hematological toxicity in vivo.
| Name | ABC 1183 |
|---|
| Description | ABC1183 is a potent, selective, orally active GSK3α/β and CDK9 inhibitor with IC50 of 327/657 nM and 321 nM (CDK9/cyclin T1), shows growth inhibitory activity against a broad panel of cancer cell lines; decreases cell survival through G2/M arrest and modulates oncogenic signaling through changes in GSK3, GS and β-catenin phosphorylation and MCL1 expression; suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms without organ or hematological toxicity in vivo. |
|---|---|
| References | References 1. Schrecengost RS, et al. J Pharmacol Exp Ther. 2018 Feb 6. pii: jpet.117.245738. View Related Products by Target GSK-3 |
| Molecular Formula | C18H14N4OS |
|---|---|
| Molecular Weight | 334.397 |