1135219-23-6
1135219-23-6 structure
- Name: ALW-II-49-7
- Chemical Name: ALW-II-49-7
- CAS Number: 1135219-23-6
- Molecular Formula: C21H17F3N4O2
- Molecular Weight: 414.388
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Ephrin Receptor
- Create Date: 2020-01-11 20:24:49
- Modify Date: 2024-01-21 19:21:41
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ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines.
| Name | ALW-II-49-7 |
|---|
| Description | ALW-II-49-7 (DDR2-IN-1) is a potent, selective DDR2 inhibitor with IC50 of 18.6 nM, also shows ability to inhibit DDR1 and Ephrin-family kinases (IC50=40 nM for EphB2); displays excellent overall kinase selectivity against a panel of over 350 kinases; decreases DDR2 phosphorylation but has little effect on the proliferation of DDR2 mutated cancer cell lines. |
|---|---|
| References | References 1. Terai H, et al. ACS Chem Biol. 2015 Dec 18;10(12):2687-96. 2. Choi Y, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. View Related Products by Target Discoidin Domain Receptor (DDR) |
| Molecular Formula | C21H17F3N4O2 |
|---|---|
| Molecular Weight | 414.388 |