1237541-73-9
1237541-73-9 structure
- Name: NAB-14
- Chemical Name: NAB-14
- CAS Number: 1237541-73-9
- Molecular Formula: C20H21N3O3
- Molecular Weight: 351.406
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2020-01-20 11:09:56
- Modify Date: 2023-01-15 13:47:02
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NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons.
| Name | NAB-14 |
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| Description | NAB-14 is a potent, selective negative allosteric modulator of GluN2C/2D-containing NMDA receptors with IC50 of 580 nM, >800-fold selective over GluN2A/GluN2 receptors; inhibits triheteromeric (GluN1/GluN2A/GluN2C) NMDARs with modestly reduced potency and efficacy compared to diheteromeric (GluN1/GluN2C/GluN2C) receptors; inhibits GluN2D-mediated synaptic currents in rat subthalamic neurons and mouse hippocampal interneurons, but has no effect on synaptic transmission in hippocampal pyramidal neurons. |
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| References | References 1. Swanger SA, et al. ACS Chem Neurosci. 2018 Feb 21;9(2):306-319. View Related Products by Target iGluR |
| Molecular Formula | C20H21N3O3 |
|---|---|
| Molecular Weight | 351.406 |