1446311-56-3
1446311-56-3 structure
- Name: SMN-C2
- Chemical Name: SMN-C2
- CAS Number: 1446311-56-3
- Molecular Formula: C24H27N5O2
- Molecular Weight: 417.513
- Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
- Create Date: 2020-01-18 09:34:36
- Modify Date: 2022-11-21 11:15:35
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SMN-C2 is a close analogs of RG-7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing; directly binds to the AGGAAG motif on exon 7 of the SMN2 pre-mRNA, and promotes a conformational change in two to three unpaired nucleotides at the junction of intron 6 and exon 7 in both in vitro and in-cell models; increases binding of the splicing modulators, far upstream element binding protein 1 (FUBP1) and its homolog, KH-type splicing regulatory protein (KHSRP), to the SMN-C2/C3-SMN2 pre-mRNA complex and enhances SMN2 splicing.
| Name | SMN-C2 |
|---|
| Description | SMN-C2 is a close analogs of RG-7916 act as selective RNA-binding ligands that modulate pre-mRNA splicing; directly binds to the AGGAAG motif on exon 7 of the SMN2 pre-mRNA, and promotes a conformational change in two to three unpaired nucleotides at the junction of intron 6 and exon 7 in both in vitro and in-cell models; increases binding of the splicing modulators, far upstream element binding protein 1 (FUBP1) and its homolog, KH-type splicing regulatory protein (KHSRP), to the SMN-C2/C3-SMN2 pre-mRNA complex and enhances SMN2 splicing. |
|---|---|
| References | References 1. Wang J, et al. Proc Natl Acad Sci U S A. 2018 Apr 30. pii: 201800260. View Related Products by Target SMN2 Modulator |
| Molecular Formula | C24H27N5O2 |
|---|---|
| Molecular Weight | 417.513 |